What question did this study set out to answer?

To characterize and compare distinct type IIa IgG-binding proteins expressed by a single isolate of group A streptococcus.

May 1, 1992The Journal of ImmunologyOpen Access

Identification of two type IIa IgG-binding proteins expressed by a single group A streptococcus

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Authors

RORonald A. OttenASML (Netherlands)RRRoberta RaederUniversity of Toledo Medical Center DHDavid G. HeathUniversity of Wyoming

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Implication

In vitro study reveals two distinct type IIa IgG-binding proteins in a single group A streptococcal strain, indicating structural heterogeneity despite identical antibody-binding profiles.

Key Points

To characterize and compare distinct type IIa IgG-binding proteins expressed by a single isolate of group A streptococcus.
Solubilized surface proteins from group A streptococcal isolate 64/14 using cyanogen bromide (CNBr) treatment.
Evaluated functional binding affinity toward human IgG1, IgG2, and IgG4 subclasses and generated monospecific polyclonal antibodies to assess antigenic cross-reactivity.
Identified two different molecular weight proteins displaying identical functional reactivity toward human IgG1, IgG2, and IgG4.
Observed no antigenic cross-reactivity between the two protein forms, with the smaller variant showing structural identity or close relation to recombinant type IIa protein from strain CS110.

Cite This Study

Otten et al. (1992) studied this question.

synapsesocial.com/papers/6a759d551cd7cac218600114 https://doi.org/10.4049/jimmunol.148.10.3174

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Implication

In vitro study reveals two distinct type IIa IgG-binding proteins in a single group A streptococcal strain, indicating structural heterogeneity despite identical antibody-binding profiles.

Identification of two type IIa IgG-binding proteins expressed by a single group A streptococcus

Discussion

Member takes

Implication

Key Points

Cite This Study

Identification of two type IIa IgG-binding proteins expressed by a single group A streptococcus

Discussion

Member takes

Implication

Key Points

Cite This Study

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