What question did this study set out to answer?

To evaluate and compare the physical, chemical, and immunologic properties of two purified M protein fractions isolated from Group A, type 12 Streptococcus.

July 1, 1971The Journal of Immunology

Further Characterization of Purified Fractions of M Protein from A Strain of Group A, Type 12 Streptococcus

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Authors

KVKenneth L. VostiStanford Medicine RJRudolph H. JohnsonUnited States Department of Veterans Affairs MDMichael F. DillonStanford University

Discussion

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Implication

Biochemical analysis demonstrates protective immunogenicity and homogeneity in purified fraction b of streptococcal M protein, suggesting defined structural relationships in type 12 strains.

Key Points

To evaluate and compare the physical, chemical, and immunologic properties of two purified M protein fractions isolated from Group A, type 12 Streptococcus.
Characterized two purified M protein fractions ('a' and 'b') from type 12 streptococci across physical, chemical, and immunologic criteria.
Assessed molecular weight, terminal amino acid composition, and capacity to stimulate bactericidal antibody production.
Fraction 'b' maintained physical, chemical, and immunologic homogeneity, exhibiting a molecular weight of 32,000, N-terminal alanine, and C-terminal leucine.
Fraction 'b' stimulated the formation of bactericidal antibodies while lacking the nontype-specific determinants identified in fraction 'a'.
Variations in molecular weight and antigenic complexity between fractions 'a' and 'b' revealed distinct structural relationships among type 12 streptococcal M protein molecules.

Cite This Study

Vosti et al. (1971) studied this question.

synapsesocial.com/papers/6a95d27046cd8039cb92c601 https://doi.org/10.4049/jimmunol.107.1.104

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Implication

Biochemical analysis demonstrates protective immunogenicity and homogeneity in purified fraction b of streptococcal M protein, suggesting defined structural relationships in type 12 strains.

Further Characterization of Purified Fractions of M Protein from A Strain of Group A, Type 12 Streptococcus

Discussion

Member takes

Implication

Key Points

Cite This Study

Further Characterization of Purified Fractions of M Protein from A Strain of Group A, Type 12 Streptococcus

Discussion

Member takes

Implication

Key Points

Cite This Study

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