Plasma Apolipoprotein C-III Levels, Triglycerides, and Coronary Artery Calcification in Type 2 Diabetics
Key result
Higher plasma ApoC-III levels in patients with type 2 diabetes were positively associated with coronary artery calcification (Tobit regression ratio 1.78; 95% CI 1.27-2.50; P<0.001).
Why the study?
Are plasma ApoC-III levels associated with coronary artery calcification in patients with type 2 diabetes mellitus?
Population
1422 subjects with type 2 diabetes mellitus (T2DM) but without clinically manifest coronary heart disease
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May support ApoC-III monitoring in diabetic patients; hypothesis-generating and leaves causal role in calcification open.
Key Points
- To investigate the relationships among plasma apolipoprotein C-III, triglyceride concentrations, and subclinical coronary artery calcification in patients with type 2 diabetes mellitus.
- Conducted a cross-sectional study of 1,422 individuals with type 2 diabetes mellitus and without clinically manifest coronary heart disease.
- Measured plasma ApoC-III, circulating lipid fractions, and glycemic markers, modeling coronary artery calcification via Tobit regression with adjustment for demographic and lipid variables.
- Plasma ApoC-III levels positively correlated with total cholesterol (r=0.36), triglycerides (r=0.59), LDL cholesterol (r=0.16), fasting glucose (r=0.16), and HbA1c (r=0.12; P<0.0001 for all).
- ApoC-III was significantly associated with coronary artery calcification in age-, sex-, and race-adjusted models (Tobit regression ratio: 1.78, 95% CI: 1.27–2.50 per SD increase; P<0.001).
- The association with calcification attenuated after adjusting for triglycerides (Tobit regression ratio: 1.43, 95% CI: 0.94–2.18; P=0.086) and separately for VLDL cholesterol (ratio: 1.14, 95% CI: 0.75–1.71; P=0.53).
Study Design
Type
Cross-Sectional (n=1,422)
Structured PICO
Are plasma ApoC-III levels associated with coronary artery calcification in patients with type 2 diabetes mellitus?
P
Population
1,422 subjects with type 2 diabetes mellitus but without clinically manifest coronary heart disease.
E
Exposure
Plasma Apolipoprotein C-III (ApoC-III) levels
O
Outcome
Coronary artery calcificationsurrogate
Main Result
Effect estimate: Tobit regression ratio 1.78 (95% CI 1.27-2.50)
p-value: p=<0.001
In patients with type 2 diabetes, increased plasma ApoC-III is associated with higher triglycerides and coronary artery calcification, suggesting it may be a therapeutic target for reducing cardiovascular risk.
Cite This Study
Qamar et al. (2015) conducted a cross-sectional in Type 2 diabetes mellitus (n=1,422). Plasma ApoC-III levels was evaluated on Coronary artery calcification (Tobit regression ratio 1.78, 95% CI 1.27-2.50, p=<0.001). Higher plasma ApoC-III levels in patients with type 2 diabetes were positively associated with coronary artery calcification (Tobit regression ratio 1.78; 95% CI 1.27-2.50; P<0.001).