What is the clinical evidence from this study?

Study design: Review. Population: Diabetes mellitus and hypertriglyceridemia. Intervention: Apolipoprotein CIII.

What question did this study set out to answer?

To review and delineate the biological mechanisms linking elevated apolipoprotein CIII levels with the deterioration of carbohydrate homeostasis and diabetes.

December 17, 2018Diabetes/Metabolism Research and Reviews

Apolipoprotein CIII and diabetes. Is there a link?

View Full Paper

Ask AI

Bookmark

Key result

Elevated Apolipoprotein CIII is associated with hypertriglyceridemia and deterioration of carbohydrate homeostasis through mechanisms including pancreatic β-cell apoptosis and insulin resistance.

Why the study?

ApoCIII concentration is high in individuals with diabetes mellitus, indicating a potential positive correlation with impairment of glucose metabolism.

Design

Review based on a PubMed search until August 2018

Authors

ECEliza ChristopoulouHippocrateon Private Hospital VTVasilis TsimihodimosUniversity of Ioannina TFTheodosios D. FilippatosUniversity of Crete

Discussion

Member takes

Implication

ApoCIII modulation merits testing for dual lipid-glucose benefits; hypothesis-generating without randomized outcome data.

Key Points

To review and delineate the biological mechanisms linking elevated apolipoprotein CIII levels with the deterioration of carbohydrate homeostasis and diabetes.
Conducted a structured literature review based on a PubMed database search of studies published up to August 2018.
Synthesized molecular, preclinical, and clinical data examining the physiological impacts of ApoCIII on lipid clearance, pancreatic function, and insulin action.
ApoCIII triggers pancreatic beta-cell apoptosis by elevating cytoplasmic calcium levels in insulin-secreting cells.
Overexpression of ApoCIII promotes non-alcoholic fatty liver disease and activates inflammatory pathways in skeletal muscle, directly impairing insulin signaling and driving insulin resistance.
ApoCIII inhibits lipoprotein lipase in the hypothalamus and systemic circulation while disrupting the protective, antiglycemic properties of high-density lipoproteins.

Structured PICO

Population

Individuals with diabetes mellitus and hypertriglyceridemia (review context)

Exposure

Apolipoprotein CIII (ApoCIII) modulation (conceptual)

Outcome

Mechanisms linking ApoCIII and deterioration of carbohydrate homeostasis

ApoCIII is mechanistically linked to insulin resistance and beta-cell apoptosis, suggesting its modulation could treat both hypertriglyceridemia and impaired carbohydrate metabolism.

Cite This Study

Christopoulou et al. (2018) conducted a review in Diabetes mellitus and hypertriglyceridemia. Apolipoprotein CIII was evaluated. Elevated Apolipoprotein CIII is associated with hypertriglyceridemia and deterioration of carbohydrate homeostasis through mechanisms including pancreatic β-cell apoptosis and insulin resistance.

synapsesocial.com/papers/6a7d9fdf9c5f03601cb86b67 https://doi.org/10.1002/dmrr.3118

View Full Paper

Ask AI

Bookmark

Apolipoprotein CIII and diabetes. Is there a link?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Apolipoprotein CIII and diabetes. Is there a link?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider