Radiolabeled microspheres were injected into the left cardiac ventricle in healthy adult dogs to quantify blood flow in maxillary and mandibular alveolar bone. Heart rate, arterial blood pressure and pulse contour were monitored throughout each experiment. Blood flow in maxillary alveolar bone was more than 30 % greater (p < .001) than in mandibular alveolar bone. Alveolar bone blood flow (mean ± S.D.) measured as ml/min per gram was 0.12 ± .02 in the maxilla compared to 0.09 ± .02 in the mandible. The cardiovascular paramenters monitored were constant immediately prior to the injection of microspheres and remained unchanged during and following injection. It is possible that radiolabeled microspheres can be used to quantify the circulatory changes in alveolar bone during the development of destructive periodontal disease in dogs.
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Kaplan et al. (1978) studied this question.