Why the study?
Does the radioactive microsphere method accurately measure cardiac output compared to the indocyanine green dye dilution method in a rabbit model?
Does the radioactive microsphere method accurately measure cardiac output compared to the indocyanine green dye dilution method in a rabbit model?
The radioactive microsphere method provides a simple and accurate way to measure regional blood flow and cardiac output in small laboratory animals.
Supports microsphere accuracy for cardiac output in rabbits; extends validation for regional flow studies in small animals.
The determination of regional blood flow and cardiac output with radioactively labeled microspheres and a reference arterial sample has been assessed in the rabbit. Paired determinations of cardiac output with the microsphere and indocyanine green dye dilution methods correlated well (F=236; p<< 0.001; N=98). A simple method for administering microspheres with a 1.5% accuracy has been developed. Paired samples drawn simultaneously revealed mixing and streaming errors of 5.3%. Regional flows to several organs determined by the method were in accord with published data. The advantages of microsphere-reference sample method include: simplicity, accuracy, the provision of regional flows without simultaneously determining cardiac output, and applicability to small laboratory animals and low flow states.
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Bartrum et al. (1974) studied this question.
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