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March 1, 1990AJP Gastrointestinal and Liver Physiology

Splanchnic and systemic hemodynamics in mice using a radioactive microsphere technique

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Population

Mice (n=22)

Comparison

Injection of radiolabeled microspheres into the… vs Conventional technique of radiolabeled…

Design

Preclinical

Authors

SSShiv Kumar SarinUniversity of DelhiCSCarlo SabbàAlbert Einstein College of MedicineRGR. J. GroszmannYale University

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Implication

Supports carotid microsphere injection for mouse hemodynamics; leaves open validation before wider cardiovascular research adoption.

Structured PICO

P
Population
Mice (n=22)
I
Intervention
Injection of radiolabeled microspheres into the carotid artery close to the aortic arch
C
Comparator
Conventional technique of radiolabeled microsphere injection into the left ventricle
O
Outcome
Feasibility and accuracy of measuring systemic and regional hemodynamics (adequate mixing and number of microspheres in tissues)surrogate

The radioactive microsphere technique can be successfully adapted for hemodynamic studies in mice by utilizing carotid artery injection rather than left ventricular injection.

Limitations

  • Five of 22 animals had to be excluded because of either a low number of microspheres in tissues or inadequate mixing of microspheres with blood

Cite This Study

Sarin et al. (1990) studied this question.

synapsesocial.com/papers/6a91210b3ef1f7fbbf3e883fhttps://doi.org/10.1152/ajpgi.1990.258.3.g365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of the Microsphere Method for Determination of Cardiac Output and Flow Distribution in the Rat2008 · 28 citations
  2. 2Hemodynamic disturbances in the rat as a function of the number of microspheres injected1983 · 67 citations
  3. 3Considerations in use of microspheres for flow measurements in anesthetized rat1986 · 40 citations
  4. 4A Simple Radioactive Microsphere Method for Measuring Regional Flow and Cardiac Output1974 · 102 citations
  5. 5Visualizing Regional Myocardial Blood Flow in the Mouse2013 · 23 citations