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December 1, 1983AJP Heart and Circulatory Physiology

Hemodynamic disturbances in the rat as a function of the number of microspheres injected

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Population

Conscious rats

Design

Preclinical

Authors

KSK. A. StanekNorthwest Medical RehabilitationTSThomas L. SmithWake Forest UniversityWMWilliam R. MurphyWichita State University

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Implication

May inform microsphere dosing in conscious rat models; leaves open translation to other species or clinical use.

Structured PICO

P
Population
Conscious rats
I
Intervention
Injection of radioactive microspheres into the left atrium using a dextrose solution (specific gravity 1.3) as suspension media and Ficoll-70 as fluid replacement
O
Outcome
Hemodynamic disturbances measured by electromagnetic flowmetrysurrogate

This study establishes the safe limits for the number of radioactive microspheres that can be injected in conscious rats without causing hemodynamic disturbances.

Cite This Study

Stanek et al. (1983) studied this question.

synapsesocial.com/papers/6a8aa81abc8a49327d722b48https://doi.org/10.1152/ajpheart.1983.245.6.h920
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Microsphere Suspension Agents of Systemic Hemodynamics in Rats. Comparison of Nonradioactive Colored and Radioactive Microspheres.1994 · 6 citations
  2. 2Considerations in use of microspheres for flow measurements in anesthetized rat1986 · 40 citations
  3. 3Evaluation of the Microsphere Method for Determination of Cardiac Output and Flow Distribution in the Rat2008 · 28 citations
  4. 4Splanchnic and systemic hemodynamics in mice using a radioactive microsphere technique1990 · 50 citations
  5. 5Microsphere estimates of blood flow: methodological considerations1988 · 17 citations