Key result
Replacement of volume loss for reference samples with dextran 70 ensures stable blood flow to all organs over a 120-minute period during microsphere blood flow estimation in dogs.
Population
30 dogs (18 conscious and 12 anesthetized)
Comparison
Radioactive microsphere technique for blood flow… vs Internal comparisons
Design
Preclinical
Follow-up
120 min
Authors
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Should not inform clinical care; leaves open refinement of microsphere protocols in non-canine models.
In experimental animal models using the microsphere technique, replacing volume loss from reference sampling with dextran 70 ensures stable blood flow measurements over time.
Ritter et al. (1988) studied Experimental blood flow measurement (n=30). Microsphere technique with volume replacement using dextran 70 vs. No volume replacement was evaluated on Blood flow estimates (gastric mucosal, pancreatic, and cardiac output). Replacement of volume loss for reference samples with dextran 70 ensures stable blood flow to all organs over a 120-minute period during microsphere blood flow estimation in dogs.
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