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March 20, 2013Circulation ResearchOpen Access

Visualizing Regional Myocardial Blood Flow in the Mouse

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Population

Isolated perfused mice hearts and a coronary artery ligation model in mice

Design

Preclinical

Authors

MKMelissa A. KruegerUniversity of WashingtonSHSabine HukeUniversity of Alabama at BirminghamRGRobb W. GlennyUniversity of Washington

Discussion

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Implication

Enables detailed perfusion mapping in mouse ischemia models; hypothesis-generating for clinical translation, requiring validation before any practice impact.

Structured PICO

P
Population
Isolated perfused mice hearts and a coronary artery ligation model in mice
I
Intervention
15-µm fluorescent microspheres combined with novel statistical and visualization methods
O
Outcome
Spatial distribution of regional myocardial blood flowsurrogate

This study provides a novel, high-resolution method for visualizing and statistically analyzing regional myocardial blood flow in mouse models, overcoming limitations of traditional microsphere techniques.

Cite This Study

Krueger et al. (2013) studied this question.

synapsesocial.com/papers/6a1f5833da07783dec2353f6https://doi.org/10.1161/circresaha.113.301162

Topics

Coronary artery diseaseCoronary CT angiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transmural coronary flow reserve patterns in dogs1986 · 57 citations
  2. 2The 400 microsphere per piece “rule” does not apply to all blood flow studies2000 · 27 citations
  3. 3Commonly Used Numbers of Microspheres Affect Cardiac Vascular Resistance2003 · 4 citations
  4. 4An analysis of eight 95 per cent confidence intervals for a ratio of Poisson parameters when events are rare2008 · 12 citations
  5. 5In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging2005 · 77 citations