Key result
Polyphenolic antioxidants show potential as auxiliary agents against oxidative stress toxicity induced by anticancer chemotherapeutics, though optimal dosing and delivery systems require further study.
Why the study?
Polyphenols have been investigated to counteract adverse effects of anticancer chemotherapeutics, prompting an examination of clinical and preclinical evidence on their use against chemotherapy-induced oxidative stress toxicity.
Do polyphenolic compounds act as effective auxiliary agents to counteract oxidative stress toxicity induced by antitumor drugs in patients undergoing chemotherapy?
Do polyphenolic compounds act as effective auxiliary agents to counteract oxidative stress toxicity induced by antitumor drugs in patients undergoing chemotherapy?
Polyphenolic compounds may serve as auxiliary agents to counteract oxidative stress toxicity from anticancer chemotherapeutics, though optimization of delivery and dosing is required.
Polyphenolic compounds, encompassing flavonoids (e.g., quercetin, rutin, cyanidin) and non-flavonoids (e.g., gallic acid, resveratrol, curcumin), show several health-related beneficial effects, which include antioxidant, anti-inflammatory, hepatoprotective, antiviral, and anticar-cinogenic properties, as well as the prevention of coronary heart diseases. Polyphenols have been also investigated for their counteraction against adverse effects of common anticancer chemo-therapeutics. This review examines the outcomes of clinical studies (and related preclinical data) over the last ten years, with a focus on the use of polyphenols in chemotherapy as auxiliary agents acting against oxidative stress toxicity induced by antitumor drugs. While further clinical studies are needed to establish adequate doses and optimal delivery systems, the improvement in pol-yphenols’ metabolic stability and bioavailability, through implementation of nanotechnologies currently being investigated, could improve therapeutic applications of their pharmaceutical or nutraceutical preparations in tumor chemotherapy.
No takes yet. Share an insight, caveat, or question.
Purgatorio et al. (2023) conducted a review in Oxidative stress toxicity induced by antitumor drugs. Polyphenolic antioxidants was evaluated. Polyphenolic antioxidants show potential as auxiliary agents against oxidative stress toxicity induced by anticancer chemotherapeutics, though optimal dosing and delivery systems require further study.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: