Population
Cell-attached membrane patches from rabbit ventricular myocytes
Comparison
Disopyramide and flecainide vs Drug-free conditions
Design
Preclinical
Authors
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These channel effects in animal preparations should not alter antiarrhythmic prescribing; hypothesis-generating for differential Kir channel actions.
Flecainide stabilizes the inward rectifier K+ channel in an inactivated state, whereas disopyramide's action potential prolonging effects appear unrelated to blocking this channel.
Martin et al. (1994) studied this question.
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