Key result
Nonobese patients with type 2 diabetes mellitus had significantly higher serum adenosine deaminase levels compared to healthy controls (38.77 vs 17.02 U/L; P < 0.0001).
Why the study?
Are serum adenosine deaminase (ADA) levels elevated in nonobese patients with type 2 diabetes mellitus compared to healthy controls?
Case-Control (n=101)
Are serum adenosine deaminase (ADA) levels elevated in nonobese patients with type 2 diabetes mellitus compared to healthy controls?
Absolute Event Rate: 38.77% vs 17.02%
p-value: p=< 0.0001
Serum ADA levels are significantly elevated in nonobese T2DM patients and correlate strongly with fasting plasma glucose, suggesting a potential association with the disease in this population.
Elevated ADA in nonobese T2DM may reflect metabolic stress; hypothesis-generating and requires prospective validation before clinical use.
The role of inflammation being minimal in the pathogenesis of type 2 diabetes mellitus (T2DM) in nonobese patients; the aim of the study was to investigate the role of adenosine deaminase (ADA) and see its association with diabetes mellitus. The preliminary case control study comprised of 56 cases and 45 healthy controls which were age and sex matched. 3 mL venous blood samples were obtained from the patients as well as controls after 8-10 hours of fasting. Serum ADA and routine biochemical parameters were analyzed. Serum ADA level was found significantly higher among nonobese T2DM subjects with respect to controls (38.77 ± 14.29 versus 17.02 ± 5.74 U/L; P < 0.0001). Serum ADA level showed a significant positive correlation with fasting plasma glucose (r = 0.657; P < 0.0001) level among nonobese T2DM subjects, but no significant correlation was observed in controls (r = -0.203; P = 0.180). However, no correlation was observed between serum ADA level compared to BMI and HbA1c levels. Our study shows higher serum ADA, triglycerides (TG) and fasting plasma glucose (FPG) levels in nonobese T2DM patients, and a strong correlation between ADA and FPG which suggests an association between ADA and nonobese T2DM subjects.
No takes yet. Share an insight, caveat, or question.
Khemka et al. (2013) conducted a case-control in Nonobese type 2 diabetes mellitus (n=101). Nonobese type 2 diabetes mellitus vs. Healthy controls was evaluated on Serum adenosine deaminase (ADA) level (p=< 0.0001). Nonobese patients with type 2 diabetes mellitus had significantly higher serum adenosine deaminase levels compared to healthy controls (38.77 vs 17.02 U/L; P < 0.0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: