Why the study?
Does a Zn-deficient diet aggravate hypertension in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR)
Comparison
Zn-deficient diet for 4 weeks vs Standard diet for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
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Zn deficiency may worsen hypertension in this model; leaves open human relevance and should not change practice.
Does a Zn-deficient diet aggravate hypertension in spontaneously hypertensive rats?
Zinc deficiency aggravates hypertension in spontaneously hypertensive rats, likely through increased oxidative stress due to reduced Cu/Zn-SOD activity.
Sato et al. (2002) studied this question.
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