February 1, 2000Journal of Biological ChemistryOpen Access

Reversible Inhibition of the Calcium-pumping ATPase in Native Cardiac Sarcoplasmic Reticulum by a Calmodulin-binding Peptide

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Population

Rabbit cardiac sarcoplasmic reticulum vesicles and isolated perfused, spontaneously beating rabbit heart…

Design

Preclinical

Authors

AXAnde XuWestern University NNNjanoor NarayananJSS Academy of Higher Education and Research

Discussion

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Implication

Suggests membrane calmodulin regulates cardiac SR calcium pumping; leaves open its role in diastolic dysfunction in vivo.

Structured PICO

Population

Rabbit cardiac sarcoplasmic reticulum (SR) vesicles and isolated perfused, spontaneously beating rabbit heart preparations

Intervention

Synthetic, high affinity CaM-binding peptide (CaM BP; amino acid sequence, LKWKKLLKLLKKLLKLG)

Outcome

ATP-energized Ca(2+) uptake, Ca(2+)-stimulated ATP hydrolysis, and CaM kinase-mediated protein phosphorylationsurrogate

Membrane-bound calmodulin plays a critical role in controlling the velocity of calcium pumping in native cardiac sarcoplasmic reticulum, impacting cardiac contractility and diastolic function.

Cite This Study

Xu et al. (2000) studied this question.

synapsesocial.com/papers/6a75a3f6ef3d015f2ddd7f6e https://doi.org/10.1074/jbc.275.6.4407

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Reversible Inhibition of the Calcium-pumping ATPase in Native Cardiac Sarcoplasmic Reticulum by a Calmodulin-binding Peptide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reversible Inhibition of the Calcium-pumping ATPase in Native Cardiac Sarcoplasmic Reticulum by a Calmodulin-binding Peptide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider