Population
Saponin skinned strips of rat caudal artery and canine aortic actomyosin
Comparison
Exogenous calmodulin and calmodulin inhibitors vs Control/baseline without exogenous calmodulin or…
Design
Preclinical
Authors
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Does not support direct calmodulin modulation of sarcoplasmic reticulum calcium transport in vascular smooth muscle; leaves open nonspecific antagonist effects.
In vascular smooth muscle, calmodulin does not directly modulate inward calcium transport by the sarcoplasmic reticulum, and the effects of calmodulin antagonists at high concentrations appear nonspecific.
Stout et al. (1992) studied this question.
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