Why the study?
Does intracellular application of calmidazolium increase Ca2+ current in cultured vascular smooth muscle cells?
Population
Cultured vascular smooth muscle (VSM) cells (A7r5 cell line)
Comparison
Intracellular application of 1 µM calmidazolium… vs Control (no calmidazolium)
Design
Preclinical
Authors
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Calmidazolium may augment L-type Ca currents in VSMCs; this in vitro observation leaves open its relevance to vascular tone regulation.
Does intracellular application of calmidazolium increase Ca2+ current in cultured vascular smooth muscle cells?
Calmidazolium stimulates L-type Ca2+ currents in vascular smooth muscle cells, likely by increasing intracellular cAMP through the inhibition of CaM-dependent phosphodiesterase rather than direct regulation by the CaM/CaMK-II pathway.
Sunagawa et al. (1998) studied this question.
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