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February 25, 2003Antimicrobial Agents and ChemotherapyOpen Access

A Point Mutation in the 14α-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus

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Authors

TDTeresa M. Dı́az-GuerraInstituto de Salud Carlos IIIEMEmilia MelladoInstituto de Salud Carlos IIIMCManuel Cuenca‐EstrellaInstituto de Salud Carlos III

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Dı́az-Guerra et al. (2003) studied this question.

synapsesocial.com/papers/6a75a59cdcfefe9676dd86d8https://doi.org/10.1128/aac.47.3.1120-1124.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An <i>Aspergillus fumigatus</i> alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity1992 · 148 citations
  2. 2Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in <i>Candida albicans</i> Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients2001 · 476 citations
  3. 3In-vivo itraconazole resistance of Aspergillus fumigatus in systemic murine aspergillosis1999 · 47 citations
  4. 4<i>Aspergillus fumigatus</i> and Aspergillosis1999 · 2,316 citations
  5. 5Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans1999 · 96 citations