Key result
Patients with Parkinson's disease exhibited lower heart rate variability compared to healthy controls, including reduced RMSSD, indicating cardiac autonomic nerve damage.
Why the study?
The correlation between Parkinson's disease and cardiac autonomic nerve function damage required exploration.
Does early Parkinson's disease reduce heart rate variability compared to healthy controls?
Meta-Analysis (n=834)
Does early Parkinson's disease reduce heart rate variability compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Heart rate variability is significantly reduced in early Parkinson's disease patients compared to healthy individuals, indicating early cardiac autonomic nerve damage and suggesting HRV could be a useful non-invasive monitoring tool.
目的：探讨帕金森病(PD)与心脏自主神经功能损伤的相关性。方法：计算机检索Pubmed、Embase、Cochrane Library、Web of Science、中国知网(CNKI)、万方(Wanfang)、维普(VIP)数据库，检索时限均为建库至2023年11月25日。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后，采用RevMan 5.4软件和Stata软件进行Meta分析。结果：共纳入17项研究，包括404例患者和430例健康对照。Meta分析结果显示：PD患者的HF [SMD: −0.28, CI (−0.53, −0.03), P = 0.03]、TP [SMD: −1.31, CI (−1.74, −0.88), P SMD: −0.84, CI (−1.06, −0.62), P SMD:−0.45, CI (−0.70, −0.21), P SMD: −1.21, CI (−2.29, −0.13), P = 0.03]均低于对照组，而两组在LF [SMD: −0.17, CI (−0.55, 0.22), P = 0.40]和LF/HF [SMD: 0.04, CI (−0.54, 0.62), P = 0.10]的差异无统计学意义。结论：PD患者的HRV明显低于正常健康人，表明PD与心脏自主神经损伤存在联系。Objective: To explore the correlation between Parkinson’s disease (PD) and cardiac autonomic nerve function damage. Methods: Computerized searches were conducted in Pubmed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases from their inception to November 25, 2023. Two reviewers independently screened the literature, extracted data, and evaluated the risk of bias in the included studies. Meta-analysis was performed using RevMan 5.4 and Stata software. Results: A total of 17 studies were included, involving 404 patients with PD and 430 healthy controls. The meta-analysis results showed that the HF [SMD: −0.28, CI (−0.53, −0.03), P = 0.03], TP [SMD: −1.31, CI (−1.74, −0.88), P SMD: −0.84, CI (−1.06, −0.62), P SMD: −0.45, CI (−0.70, −0.21), P SMD: −1.21, CI (−2.29, −0.13), P = 0.03] of patients with PD were all lower than those of the control group, while there was no statistically significant difference in LF [SMD: −0.17, CI (−0.55, 0.22), P = 0.40] and LF/HF [SMD: 0.04, CI (−0.54, 0.62), P = 0.10] between the two groups. Conclusion: The HRV of patients with PD is significantly lower than that of normal healthy individuals, indicating a connection between PD and cardiac autonomic nerve damage.
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致春 刘 (2025) conducted a meta-analysis in Parkinson's Disease (n=834). Parkinson's disease vs. Healthy controls was evaluated on RMSSD (Root mean square of successive RR interval differences) (SMD -0.84, 95% CI -1.06, -0.62, p=<0.001). Patients with Parkinson's disease exhibited lower heart rate variability compared to healthy controls, including reduced RMSSD, indicating cardiac autonomic nerve damage.
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