Key result
Intra-operative administration of 30 mL/Kg crystalloid infusion significantly reduced the requirement for rescue antiemetics (5% vs 32.5%) compared to 15 mL/Kg in patients undergoing diagnostic gynaecological laparoscopy.
Why the study?
Laparoscopic procedures, especially gynaecological surgeries, are associated with an increased incidence of post-operative nausea and vomiting.
RCT (n=160)
Double-blind
Sealed envelopes
No
May reduce rescue antiemetic needs in gynaecological laparoscopy; hypothesis-generating and requires larger confirmatory trials.
Laparoscopic procedures have the advantages of minimal incision, early recovery, lesser post-operative pain and early ambulation. However, they are associated with an increased incidence of post-operative nausea and vomiting (PONV), which is all the more frequent in gynaecological laparoscopic surgeries. In our study, we have evaluated the effectiveness of intra-operative intravenous crystalloid infusion on post-operative nausea and vomiting after diagnostic gynaecological laparoscopy.
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Halder et al. (2020) conducted an RCT in Post-operative nausea and vomiting (PONV) (n=160). Intra-operative intravenous crystalloid infusion vs. 15 mL/Kg intra-operative intravenous crystalloid infusion was evaluated on Requirement of rescue antiemetics over 12 hours post-operatively (p=0.00002). Intra-operative administration of 30 mL/Kg crystalloid infusion significantly reduced the requirement for rescue antiemetics (5% vs 32.5%) compared to 15 mL/Kg in patients undergoing diagnostic gynaecological laparoscopy.
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