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February 1, 1994AJP Heart and Circulatory Physiology

Endothelium-dependent relaxation by angiotensin-converting enzyme inhibitors in canine femoral arteries

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Why the study?

Do ACE inhibitors induce endothelium-dependent relaxation in isolated canine femoral arteries?

Population

Isolated canine femoral arteries with and without endothelium

Comparison

ACE inhibitors (M-1, an active metabolite of… vs Arteries without endothelium / baseline…

Design

Preclinical

Authors

MMMasao MoroiToho UniversityNANobuharu AkatsukaWest Virginia UniversityMFMasayuki FukazawaSaku Central Hospital

Discussion

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Implication

Endothelium-dependent ACE inhibitor relaxation in canine arteries is hypothesis-generating; leaves open translation to human vascular therapy.

Structured PICO

Do ACE inhibitors induce endothelium-dependent relaxation in isolated canine femoral arteries?

P
Population
Isolated canine femoral arteries with and without endothelium
I
Intervention
ACE inhibitors (M-1, an active metabolite of delapril, and captopril, 10(-8) to 10(-5) M)
C
Comparator
Arteries without endothelium / baseline precontracted state
O
Outcome
Vascular relaxation (endothelium-dependent)surrogate

ACE inhibitors induce endothelium-dependent relaxation in canine femoral arteries via bradykinin-mediated release of nitric oxide and prostanoids.

Cite This Study

Moroi et al. (1994) studied this question.

synapsesocial.com/papers/6a75ac0e99436945dad37540https://doi.org/10.1152/ajpheart.1994.266.2.h583
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors.1992 · 223 citations
  2. 2Endothelium dependent vasomotor responses to endogenous agonists are potentiated following ACE inhibition by a bradykinin dependent mechanism1994 · 56 citations
  3. 3Interference of Angiotensin-Converting Enzyme Inhibition with Vasoactive Peptides in the Coronary Circulation of Dogs1995 · 6 citations
  4. 4Prostaglandins Reduce the Contractile Responses to Noradrenaline and Angiotensin II in Canine Femoral Arteries After But Not Before Chronic Inhibition of Nitric Oxide Synthesis1997 · 5 citations
  5. 5Inhibition of the Angiotensin Converting Enzyme by Perindoprilat and Release of Nitric Oxide1995 · 15 citations