The 43 member companies of the Japan Pharmaceutical Manufactures Association established Pharma SNP Consortium (PSC), a non-profit organization, which will implement research projects over three years between 2000-2003 with a total budget of 1 billion yen. The following are concrete research themes of the PSC: Standardization to collect samples from human donors; informed consent, protection of privacy (anonymity, information management system, etc.), ethics committee, and procedures (blood sampling, storage, etc.). And the analysis on gene polymorphisms (SNPs) related with pharmacokinetics; to identify SNPs of approximately 180 pharmacokinetics related genes, which are drug metabolizing enzymes and drug transporters, to analyze the allelic frequency of SNPs on a general Japanese population group composed of about 800 individuals, to generate a database for the analysis of SNPs allelic frequency, and to express varia is in insect cells, analyze their function and examine the influence on the drug responses.It is hoped that the PSC's plan will contribute to the development of the healthcare by constructing a common basis for the drug response analysis.
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Miyagishima et al. (2001) studied this question.
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