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The study aims to describe a technique for separating megakaryocytes from mouse bone marrow using velocity sedimentation.

April 1, 1974BloodOpen Access

Separation of Megakaryocytes From Mouse Bone Marrow by Velocity Sedimentation

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Technique demonstrates separation of megakaryocytes by sedimentation velocities, indicating maturation stages.

The study aims to describe a technique for separating megakaryocytes from mouse bone marrow using velocity sedimentation.
Utilized a modified sedimentation chamber for separation based on unit gravity velocity sedimentation.
Identified sedimentation velocities of 30, 60, and 100 mm/hr for megakaryocytes.
Three distinct sedimentation peaks were observed for megakaryocytes, indicating variation in maturation stages.
The 30 mm/hr peak primarily contained immature megakaryocytes, while the 60 and 100 mm/hr peaks corresponded to larger, more mature forms.

Nakeff et al. (1974) studied this question.

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