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In vitro study demonstrates that ricin inhibits protein synthesis by inactivating the 60S subunit in rat liver ribosomes, indicating a subunit-specific mechanism of toxin action.
Poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes is strongly inhibited by ricin. Experiments involving hybridization between subunits derived from normal and ricin-treated ribosomes demonstrate that the 60S subunit is the site of action of the toxin. The toxin inactivates the 60S subunit independently of the presence of the 40S subunit.
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Sperti et al. (1973) studied this question.
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