Observations by Electron Microscopy on Contraction of Skeletal Myofibrils Induced With Adenosinetriphosphate

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Population

Skeletal myofibrils isolated either by tryptic digestion at 0 degrees C or by a colloid mill

Comparison

Adenosinetriphosphate and temperature elevation… vs Uncontracted fibrils

Design

Preclinical

Authors

Discussion

Animal EM observations of myofibrillar contraction; leaves open validation in human cardiac sarcomeres.

Population

Skeletal myofibrils isolated either by tryptic digestion at 0 degrees C or by a colloid mill

Intervention

Adenosinetriphosphate (0.0025 M) and temperature elevation above 0 degrees C

Comparator

Uncontracted fibrils

Outcome

Structural changes during contraction observed via electron microscopysurrogate

Demonstrates the ultrastructural changes in skeletal myofibrils during ATP-induced contraction using electron microscopy.

Ashley et al. (1951) studied this question.

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