Why the study?
Does intraarticular injection of CAEV increase interferon production in the synovial fluid of goats with CAE?
Does intraarticular injection of CAEV increase interferon production in the synovial fluid of goats with CAE?
Goats with naturally acquired CAE have high levels of interferon in their synovial fluid, which increases further upon intraarticular injection of CAEV or control inoculum.
Further elevates synovial IFN in CAE goats regardless of inoculum; leaves open specificity to viral versus nonspecific joint stimuli.
A high level of interferon (IFN) was found in the synovial fluid of goats with naturally acquired caprine arthritis-encephalitis (CAE), a disease caused by caprine arthritis-encephalitis virus (CAEV), a nononcogenic retrovirus of the lentivirus group. Intraarticular injection of CAEV or control inoculum in the joints of affected goats caused increased amounts of IFN production in synovial fluid.
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Yilma et al. (1988) studied this question.
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