Key result
Low-dose magnesium sulfate administered before anesthesia induction significantly shortened neuromuscular blocker onset time compared to midazolam and saline (83.95 vs 111.15 vs 163.7 seconds; P=0.001).
Why the study?
Data were lacking on the effects of low doses of magnesium sulfate on hemodynamics and neuromuscular blocker onset and block duration.
Does low-dose magnesium sulfate shorten the onset time and prolong the block duration of neuromuscular blockers in patients undergoing elective open cholecystectomy?
RCT (n=60)
randomized
Does low-dose magnesium sulfate shorten the onset time and prolong the block duration of neuromuscular blockers in patients undergoing elective open cholecystectomy?
Absolute Event Rate: 83.95% vs 163.7%
p-value: p=0.001
Low-dose magnesium sulfate administration before rocuronium injection significantly reduces neuromuscular agent consumption and shortens onset time without altering hemodynamics.
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Atar et al. (2021) conducted an RCT in elective open cholecystectomy (n=60). Magnesium sulfate vs. Midazolam (0.03 mg/kg) or 0.9% saline was evaluated on Neuromuscular blocker onset time (seconds) (p=0.001). Low-dose magnesium sulfate administered before anesthesia induction significantly shortened neuromuscular blocker onset time compared to midazolam and saline (83.95 vs 111.15 vs 163.7 seconds; P=0.001).
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