Key result
Magnesium sulphate cuts propofol induction doses by ~29% and reduces maintenance requirements versus placebo.
Why the study?
Magnesium sulphate has potential in balanced anesthesia to enhance patient safety, but its effect on total propofol requirements under bispectral index-targeted general anesthesia needed evaluation.
Does magnesium sulphate reduce the total dose of propofol required to maintain a constant BIS value in adult patients undergoing elective abdominal surgery under general anesthesia?
RCT (n=60)
Double-blind
Computer generated randomization
No
Does magnesium sulphate reduce the total dose of propofol required to maintain a constant BIS value in adult patients undergoing elective abdominal surgery under general anesthesia?
Absolute Event Rate: 1.7% vs 2.39%
p-value: p=<0.001
Magnesium sulphate co-administration significantly decreases the intraoperative propofol requirement to maintain targeted BIS values, though it is associated with delayed recovery.
No takes yet. Share an insight, caveat, or question.
Reduces propofol needs for BIS maintenance; supports adjunctive magnesium in abdominal surgery but cautions on delayed recovery.
Kaur et al. (2023) conducted an RCT in Elective abdominal surgery under general anesthesia (n=60). Magnesium sulphate vs. Normal saline was evaluated on Propofol required during induction (mg/kg) (p=<0.001). Magnesium sulphate co-administration significantly reduced the mean quantity of propofol required for induction (1.70 vs 2.39 mg/kg) and maintenance (4.48 vs 6.63 mg/kg/h) compared to placebo.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: