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September 16, 2025IAR Journal of Anaesthesiology and Critical Care

Effect of Magnesium Sulphate and Clonidine on Propofol Consumption, Hemodynamics and Postoperative Recovery using Bispectral Index (BIS) in Elective Surgeries

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Authors

DKDeepak C. KoliTPT.S. PatilSMSandhya P Manjrekar

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Overview

Double-blind trial assessed magnesium sulphate and clonidine's effects on propofol use and postoperative recovery.

Key Points

  • Magnesium sulphate and clonidine significantly reduced propofol consumption during induction.
  • Recovery was delayed with magnesium sulphate, while clonidine had no notable impact on heart rate or blood pressure.
  • Preoperative administration of both agents showed faster BIS reaching required levels for surgery.
  • Statistical tests confirmed significant outcomes with p 0.0001 for both drug groups compared to control.

Cite This Study

Koli et al. (2022) studied this question.

synapsesocial.com/papers/68d4768331b076d99fa6f103https://doi.org/10.47310/iarjacc.2022.v03i01.009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of magnesium sulphate on propofol requirement in abdominal surgeries under general anesthesia2023
  2. 2Compare the efficacy of pre-anaesthetic single IV dose of magnesium sulphate versus clonidine for suppression of sympathetic response to pneumoperitoneum in patients undergoing elective laparoscopic cholecystectomy2020
  3. 3Effect of Oral Clonidine Premedication on Propofol Consumption for Patient Undergoing Laparoscopic Cholecystectomy2016 · 1 citations
  4. 4Comparative Evaluation of Dexmedetomidine and Clonidine on Propofol Consumption, Haemodynamics and Postoperative Recovery in Laparoscopic Surgeries: A Prospective, Double-Blind, Placebo-Controlled, Randomised Study2024
  5. 5Comparison of oral pre-medication with clonidine and metoprolol on intraoperative hemodynamics and surgical conditions during functional endoscopic sinus surgery2024