Why the study?
Laparoscopic surgery routinely requires stable intraoperative haemodynamic states by avoiding hypertension and tachycardia, prompting a comparison of magnesium sulphate versus clonidine for maintaining perioperative haemodynamics.
Does magnesium sulphate compared to clonidine improve hemodynamic stability in patients undergoing elective laparoscopic cholecystectomy?
Population
Patients undergoing elective laparoscopic cholecystectomy
Comparison
Pre-anaesthetic single IV dose of magnesium sulphate vs clonidine
Key result
Pre-anaesthetic intravenous magnesium sulphate (50 mg/kg) significantly reduced mean arterial pressure at 5 minutes after pneumoperitoneum compared to clonidine (94.17 vs 100.97 mmHg, p<0.0001) in patients undergoing elective laparoscopic cholecystectomy.
Authors
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Should not change practice based on Level 5 evidence; leaves open whether magnesium is superior to clonidine for hemodynamic control.
RCT (n=60)
Double-blind
Computer-generated random numbers table
No
Does magnesium sulphate compared to clonidine improve hemodynamic stability in patients undergoing elective laparoscopic cholecystectomy?
Absolute Event Rate: 94.17% vs 100.97%
p-value: p=<0.0001
Reddy et al. (2020) conducted an RCT in Elective laparoscopic cholecystectomy (n=60). Magnesium sulphate vs. Clonidine 1 µg/kg IV was evaluated on Mean arterial pressure at 5 minutes after pneumoperitoneum (p=<0.0001). Pre-anaesthetic intravenous magnesium sulphate (50 mg/kg) significantly reduced mean arterial pressure at 5 minutes after pneumoperitoneum compared to clonidine (94.17 vs 100.97 mmHg, p<0.0001) in patients undergoing elective laparoscopic cholecystectomy.