Key result
The induction of hypertension markedly impaired the ability of the muscle metaboreflex to elicit increases in cardiac output and left ventricular function during dynamic exercise.
Why the study?
Does hypertension attenuate muscle metaboreflex-induced increases in cardiac function in conscious dogs?
Population
7 adult female mongrel dogs (20-25 kg) trained to run on a motor-driven treadmill
Comparison
Induction of renovascular hypertension via… vs The same animals before induction of hypertension
Design
Preclinical
Follow-up
30.9 ± 4.2 days
Authors
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May underlie exercise intolerance in hypertension; hypothesis-generating for human metaboreflex studies.
Does hypertension attenuate muscle metaboreflex-induced increases in cardiac function in conscious dogs?
p-value: p=<0.05
In a canine model, hypertension impairs the ability of the muscle metaboreflex to elicit increases in cardiac function during exercise, potentially contributing to exercise intolerance.
Sala‐Mercado et al. (2013) studied Hypertension (n=7). Induction of renovascular hypertension vs. Normotensive state (pre-induction control) was evaluated on Rise in cardiac output with muscle metaboreflex activation during mild dynamic exercise (p=<0.05). The induction of hypertension markedly impaired the ability of the muscle metaboreflex to elicit increases in cardiac output and left ventricular function during dynamic exercise.
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