Key result
Elderly patients with chronic heart failure had significantly lower plasma levels of D-series resolvin 1 and impaired T-cell responsiveness to resolvins compared to healthy controls.
Population
27 elderly patients with chronic heart failure (CHF) and 23 healthy age-matched control subjects
Comparison
Ex vivo treatment of peripheral blood… vs Healthy age-matched control subjects and…
Design
Case-control
Authors
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Suggests defective inflammation resolution in elderly HF; leaves open resolvin pathways as therapeutic targets pending validation.
Case-Control (n=50)
Chronic heart failure is associated with a defective proresolving inflammatory pathway, characterized by reduced resolvin D1 levels and impaired T-cell responsiveness due to downregulated GPR32 receptors.
Chiurchiù et al. (2018) conducted a case-control in Chronic heart failure (n=50). Chronic heart failure vs. Healthy age-matched controls was evaluated on Plasma levels of D-series resolvin (RvD)1 and T-cell responsiveness. Elderly patients with chronic heart failure had significantly lower plasma levels of D-series resolvin 1 and impaired T-cell responsiveness to resolvins compared to healthy controls.
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