Zeolite as an efficient and recyclable activation surface for the synthesis of bis-thiazolidinones: theoretical screening owing to experimental biology

Zeolite 5Å has been used as an efficient and cost effective activating catalyst for the synthesis of bis-thiazolidinones 4 (a–h) starting from bis-imines 3 (a–h) and thioacetic acid. The reactions were performed under microwave irradiation in solventless condition. The catalyst was recycled and used for several times. This reaction is scalable to multigram scale and the methodology has resulted in an efficient synthesis. A benign, environmentally friendly, efficient, and extremely fast procedure for synthesis of bis-thiazolidinones has been demonstrated. The produced bis-thiazolidinone molecules were characterized on the basis of elemental analysis, IR, mass, and 1H-NMR spectral data. The synthesized moieties were screened virtually using some of bioinformatical softwares and discussed.