What question did this study set out to answer?

To determine how cooperation between insulin-like growth factor signaling and integrin alpha v beta 5 regulates tumor cell motility and spontaneous metastatic dissemination in vivo.

March 15, 1997Journal of Clinical InvestigationOpen Access

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

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Authors

PBPeter C. BrooksMaine Medical Center RKRichard KlemkeMoores Cancer Center SSSilvia SchönScripps Research Institute

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Implication

Preclinical study demonstrates that growth factor signaling and integrin alpha v beta 5 drive pulmonary metastasis in animal models, suggesting a dual target for blocking tumor spread.

Key Points

To determine how cooperation between insulin-like growth factor signaling and integrin alpha v beta 5 regulates tumor cell motility and spontaneous metastatic dissemination in vivo.
Assessed tumor cell adhesion to vitronectin and cell motility in vitro following cytokine and growth factor stimulation.
Evaluated spontaneous pulmonary metastasis and primary tumor growth across multiple tumor cell types in chick embryo and SCID mouse/human chimeric models.
Integrin alpha v beta 5 promoted tumor cell adhesion to vitronectin, whereas cell motility required cytokine stimulation that redistributed alpha-actinin to alpha v beta 5 membrane-adhesive complexes.
Dual activation through integrin alpha v beta 5 ligation and cytokine/growth factor receptor signaling was strictly required for spontaneous lung metastasis across multiple tumor types, independent of primary tumor growth.

Cite This Study

Brooks et al. (1997) studied this question.

synapsesocial.com/papers/6a75b303dcfefe9676dd8cb0 https://doi.org/10.1172/jci119298

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Implication

Preclinical study demonstrates that growth factor signaling and integrin alpha v beta 5 drive pulmonary metastasis in animal models, suggesting a dual target for blocking tumor spread.

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

Discussion

Member takes

Implication

Key Points

Cite This Study

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

Discussion

Member takes

Implication

Key Points

Cite This Study

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