Comparison of feature-based indices derived from photoplethysmogram recorded from different body locations during lower body negative pressure

Objective Various time domain features, including dicrotic notch ( dic ), in photoplethysmogram (PPG), and the pulse transit time (PTT) determined using the simultaneously recorded electrocardiogram (ECG), are believed to have a critical role with many potential clinical applications. However, the dependence of these parameters on PPG sensor location is less well known. Approach Three transmissive pulse oximetry probes (Xhale) were put simultaneously on the ear, nose, and finger of 36 healthy volunteers in the lower body negative pressure (LBNP) experiment. Various features of the recorded PPG signals were analyzed across different LBNP phases for each location. Simultaneously recorded finger PPG and ECG (Nellcor) were used to assess the dependence of PTT on PPG sensor location. Main Results PPG signal quality varies by measurement site, with nasal PPG showing the highest quality and ear PPG the lowest. Except pulse rate (PR), most feature-related indices differ across sites. Specifically, the ratios of detectable dic vary, highest in finger PPG and lowest in nasal PPG. When dic is detectable, the e point and dic are significantly different. Pulse rate variability indices and PTT also vary by location, though no clear conclusions can be drawn about PTT behavior across different LBNP phases. Significance Various indices derived from PPG signals in a well-controlled study environment are influenced by sensor placement. Although not all possible indices are examined, the findings clearly illustrate the sensitivity of signal features to measurement location. While these results may not be directly generalizable to routine clinical settings, caution is warranted when extrapolating findings from one PPG site to another. This consideration is especially important in the digital health era, where mobile devices with PPG sensors are increasingly deployed at diverse body sites.