What question did this study set out to answer?

To compare the efficacy and remission rates between high-dose and low-dose antithyroid drug regimens in patients with Graves' hyperthyroidism.

September 1, 1983The Journal of Clinical Endocrinology & Metabolism

Comparison of Effects of High and Low Dosage Regimens of Antithyroid Drugs in the Management of Graves’ Hyperthyroidism*

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Authors

JRJoão Hamilton RomaldiniHospital do Servidor Público Estadual NBN. BrombergHospital do Servidor Público Municipal RWR. S. WernerUniversity of California San Diego Medical Center

Discussion

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Implication

Randomized trial demonstrates higher remission rates with high-dose antithyroid drug regimens in Graves' hyperthyroidism, indicating potential immunosuppressive benefits.

Key Points

To compare the efficacy and remission rates between high-dose and low-dose antithyroid drug regimens in patients with Graves' hyperthyroidism.
Randomized trial of 113 patients with Graves' hyperthyroidism assigned to high-dose antithyroid drugs with T3 add-back (Group A, n=65) or standard low-dose antithyroid drugs (Group B, n=48).
Group A received methimazole (MMI: 60 ± 14.5 mg/day) or propylthiouracil (PTU: 693 ± 173 mg/day) plus 50–75 µg T3 daily for 15.1 ± 4.2 months.
Group B received MMI (13.6 ± 7 mg/day) or PTU (180 ± 58 mg/day) alone for 13.5 ± 2.2 months, with an overall mean follow-up of 42 ± 14 months (range 17–81 months).
Remission occurred in 75.4% (49/65) of patients in the high-dose group compared to 41.6% (20/48) in the low-dose group (P < 0.001).
Patients treated with high doses exhibited a higher rate of negative thyroid-stimulating antibody tests at the end of therapy (71% vs. 29%, P < 0.01) and a significantly greater decline in microsomal antibody titers (P < 0.05).
Mean free T4 index during therapy was significantly lower in patients achieving remission compared to those who relapsed (4.8 vs. 6.5, P < 0.001) and inversely correlated with MMI (r = -0.567, P < 0.001) and PTU doses (r = -0.379, P < 0.01).

Cite This Study

Romaldini et al. (1983) studied this question.

synapsesocial.com/papers/6a75b39b06e84d3015dd80e8 https://doi.org/10.1210/jcem-57-3-563

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Implication

Randomized trial demonstrates higher remission rates with high-dose antithyroid drug regimens in Graves' hyperthyroidism, indicating potential immunosuppressive benefits.

Comparison of Effects of High and Low Dosage Regimens of Antithyroid Drugs in the Management of Graves’ Hyperthyroidism*

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of Effects of High and Low Dosage Regimens of Antithyroid Drugs in the Management of Graves’ Hyperthyroidism*

Discussion

Member takes

Implication

Key Points

Cite This Study

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