What question did this study set out to answer?

To determine whether a higher daily dose of methimazole improves long-term remission rates in patients with Graves' disease hyperthyroidism.

June 1, 1993The Journal of Clinical Endocrinology & Metabolism

A prospective randomized trial of antithyroid drug dose in Graves' disease therapy. European Multicenter Study Group on Antithyroid Drug Treatment.

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Authors

DRD. ReinweinGoethe University Frankfurt GBG. BenkerNational Institutes of Health JLJohn H. LazarusUniversity Hospital of Wales

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Implication

Randomized trial demonstrates equivalent remission but higher adverse events with high-dose methimazole in Graves' hyperthyroidism, suggesting lower doses are preferred.

Key Points

To determine whether a higher daily dose of methimazole improves long-term remission rates in patients with Graves' disease hyperthyroidism.
Prospective randomized multicenter trial across 18 European thyroid clinics enrolling 509 patients with Graves' hyperthyroidism.
Patients received either 10 mg (n=153 evaluated) or 40 mg (n=156 evaluated) daily methimazole combined with levothyroxine for 12 months, followed by 12 months of observation.
A euthyroid state was achieved more rapidly with 40 mg versus 10 mg methimazole at 3 weeks (83.1% vs 68.4%) and 6 weeks (91.6% vs 84.9%).
Relapse rates after 12 months off therapy were 35.9% in the 10 mg group compared to 37.2% in the 40 mg group, with 25% and 30% remaining positive for TSH receptor antibodies.
Adverse drug reactions were significantly higher in the 40 mg group at 26.0% (67/258) compared to 15.5% (39/251) in the 10 mg group (P < 0.01).

Cite This Study

Reinwein et al. (1993) studied this question.

synapsesocial.com/papers/6a75b39b06e84d3015dd80e5 https://doi.org/10.1210/jcem.76.6.8501160

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Implication

Randomized trial demonstrates equivalent remission but higher adverse events with high-dose methimazole in Graves' hyperthyroidism, suggesting lower doses are preferred.

A prospective randomized trial of antithyroid drug dose in Graves' disease therapy. European Multicenter Study Group on Antithyroid Drug Treatment.

Discussion

Member takes

Implication

Key Points

Cite This Study

A prospective randomized trial of antithyroid drug dose in Graves' disease therapy. European Multicenter Study Group on Antithyroid Drug Treatment.

Discussion

Member takes

Implication

Key Points

Cite This Study

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