Key result
In Chinese women, the top tertile of the ApoB/ApoA-I ratio was associated with a higher risk of diabetes and pre-diabetes compared to the bottom tertile (OR 3.65; 95% CI 1.69-6.10).
Why the study?
Is a higher ApoB/ApoA-I ratio associated with an increased risk of pre-diabetes and type 2 diabetes mellitus in Chinese adults?
Cross-Sectional (n=729)
Is a higher ApoB/ApoA-I ratio associated with an increased risk of pre-diabetes and type 2 diabetes mellitus in Chinese adults?
Odds Ratio: 3.65 (95% CI 1.69–6.1)
The ApoB/ApoA-I ratio is positively associated with the risk of pre-diabetes and type 2 diabetes in Chinese women, but not in men, suggesting a sex-specific biomarker utility.
Should not change diabetes risk assessment; leaves open incremental value of ApoB/ApoA-I beyond standard lipids in prospective studies.
BACKGROUND: Apolipoprotein B/apolipoprotein A-I (ApoB/ApoA-I) ratio is a useful predictor of cardiovascular risk. However, the association between the ApoB/ApoA-I ratio and the risk of type 2 diabetes mellitus (T2DM) is still obscure. AIMS: To investigate the associations between the ApoB/ApoA-I ratio and the risk of T2DM and pre-diabetes in a Chinese population, and to assess the role of gender in these associations. METHODS: A stratified random sampling design was used in this cross-sectional study which included 264 men and 465 women with normal glucose tolerance (NGT), pre-diabetes or T2DM. Serum ApoB, ApoA-I and other lipid and glycaemic traits were measured. Pearson's partial correlation and multivariable logistic analysis were used to evaluate the associations between ApoB/ApoA-I ratio and the risk of T2DM and pre-diabetes. RESULTS: The ApoB/ApoA-I ratios were significantly increased across the spectrum of NGT, pre-diabetes and T2DM. Women showed higher levels of ApoB/ApoA-I ratio and ApoB than men in the pre-diabetic and T2DM groups, but not in the NGT group. The ApoB/ApoA-I ratio was closely related with triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and other glycaemic traits. Moreover, in women, the risk of diabetes and pre-diabetes in the top and middle tertiles of the ApoB/ApoA-I ratio were 3.65-fold (95% CI 1.69 to 6.10) and 2.19-fold (95% CI 1.38 to 2.84) higher than in the bottom tertile, respectively, after adjusting for potential confounding factors. However, the associations disappeared in men after adjusting for other factors. CONCLUSIONS: The ApoB/ApoA-I ratio showed positive associations with the risk of diabetes and pre-diabetes in Chinese women.
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Zheng et al. (2017) conducted a cross-sectional in Type 2 diabetes mellitus and pre-diabetes (n=729). ApoB/ApoA-I ratio vs. Bottom tertile of ApoB/ApoA-I ratio was evaluated on Risk of diabetes and pre-diabetes (OR 3.65, 95% CI 1.69-6.10). In Chinese women, the top tertile of the ApoB/ApoA-I ratio was associated with a higher risk of diabetes and pre-diabetes compared to the bottom tertile (OR 3.65; 95% CI 1.69-6.10).
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