July 15, 1993New England Journal of Medicine
The Search for the Ideal Positive Inotropic Agent
Population
Patients with chronic heart failure
Design
Editorial
Authors
Discussion
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Implication
Despite favorable hemodynamic effects, positive inotropic agents have historically failed to improve clinical outcomes and often increase mortality in chronic heart failure.
Structured PICO
P
Population
Patients with chronic heart failure
I
Intervention
Positive inotropic agents (including cyclic AMP phosphodiesterase inhibitors such as milrinone)
Despite favorable hemodynamic effects, positive inotropic agents have historically failed to improve clinical outcomes and often increase mortality in chronic heart failure.
Cite This Study
Milton Packer (1993) studied this question.