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June 16, 2022Diabetes Research and Clinical PracticeOpen Access

Ethnicity and prognosis following a cardiovascular event in people with and without type 2 diabetes: Observational analysis in over 5 million subjects in England

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Key result

Following a first cardiovascular event, non-White ethnicities had lower rates of subsequent mortality and CVD events compared to White individuals (HRs 0.64-0.98), whereas type 2 diabetes increased risk.

Why the study?

To quantify ethnic differences in the risk of all-cause mortality and CVD events following a first CVD event in people with and without type 2 diabetes.

Do ethnicity and type 2 diabetes status impact the risk of mortality and recurrent cardiovascular events following a first CVD event?

Population

5,349,271 subjects with a first CVD event in England

Comparison

Different ethnicities and type 2 diabetes status

Design

Observational analysis

Authors

SRSandra RemsingSASophia AbnerKRKatharine Reeves

Discussion

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Member takes

Overview

Ethnicity and diabetes may refine post-CVD risk stratification; observational data leave mechanisms and interventions open for prospective validation.

Study Design

Type

Observational (n=5,349,271)

Structured PICO

Do ethnicity and type 2 diabetes status impact the risk of mortality and recurrent cardiovascular events following a first CVD event?

P
Population
5,349,271 subjects in England with a first cardiovascular event between 2002 and 2020, analyzed to quantify ethnic differences in subsequent prognosis.
E
Exposure
Non-White ethnicity and presence of type 2 diabetes (observational exposures)
C
Comparator
White ethnicity and absence of type 2 diabetes (reference groups)
O
Outcome
Fatal and nonfatal second CVD event (different phenotype compared to the first) and all-cause mortalityhard clinical

Main Result

Effect estimate: HR 0.64 to 0.79 (for all-cause death in men)

Following a first cardiovascular event, non-White ethnicities have lower mortality and recurrent event rates compared to White individuals, while type 2 diabetes consistently worsens prognosis across all groups.

Cite This Study

Remsing et al. (2022) conducted an observational in First cardiovascular disease (CVD) event (n=5,349,271). Non-White ethnicity vs. White ethnicity was evaluated on Fatal and nonfatal second CVD event and all-cause mortality (HR 0.64 to 0.79 (for all-cause death in men)). Following a first cardiovascular event, non-White ethnicities had lower rates of subsequent mortality and CVD events compared to White individuals (HRs 0.64-0.98), whereas type 2 diabetes increased risk.

synapsesocial.com/papers/6a75b61374b63c188eb1ef1bhttps://doi.org/10.1016/j.diabres.2022.109967
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people2014 · 1,265 citations
  2. 2Case fatality rates for South Asian and Caucasian patients show no difference 2.5 years after percutaneous coronary intervention2011 · 20 citations
  3. 3First myocardial infarctions in Asian and white men.1989 · 159 citations
  4. 4Differences between South Asians and White Europeans in five year outcome following percutaneous coronary intervention2011 · 29 citations
  5. 5Mortality differentials 1991−2005 by self-reported ethnicity: findings from the ONS Longitudinal Study2013 · 49 citations