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June 7, 2010Current Medical Research and Opinion

Premature cardiovascular events and mortality in south Asians with type 2 diabetes in the United Kingdom Asian Diabetes Study – effect of ethnicity on risk

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Key result

South Asians with T2D die ~7 years younger than white Europeans despite similar CVD risk.

  • OR 1.4
  • 95% CI 0.9-2.2
  • n=1,978

Why the study?

Does South Asian ethnicity increase the risk of cardiovascular events and mortality compared to White European ethnicity in patients with type 2 diabetes?

Population

1978 subjects with type 2 diabetes recruited from 25 general practices in Coventry and Birmingham, UK.

Comparison

South Asian ethnicity vs White European ethnicity

Design

Cohort

Follow-up

2 years

Authors

SBSrikanth BellaryJOJAMES P. OʼHARENRNeil T. Raymond

Discussion

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Overview

Suggests ethnic mortality disparities in T2D; hypothesis-generating and should not yet change practice.

Study Design

Type

Cohort (n=1,978)

Multicenter

Yes

Structured PICO

Does South Asian ethnicity increase the risk of cardiovascular events and mortality compared to White European ethnicity in patients with type 2 diabetes?

P
Population
1,978 South Asian and white European patients with type 2 diabetes from 25 UK general practices, followed for 2 years.
E
Exposure
South Asian ethnicity
C
Comparator
White European ethnicity
O
Outcome
Cardiovascular events and mortality over a 2-year periodhard clinical

Main Result

Odds Ratio: 1.4 (95% CI 0.9–2.2)

South Asian patients with type 2 diabetes in the UK die at a significantly younger age than white Europeans, emphasizing the need for ethnicity-specific cardiovascular risk management.

Limitations

  • Fewer events in both groups
  • Short period of follow-up
  • short period of follow-up

Cite This Study

Bellary et al. (2010) conducted a cohort in Type 2 diabetes (n=1,978). South Asian ethnicity vs. White European ethnicity was evaluated on CVD event or death from CVD (OR 1.4, 95% CI 0.9-2.2). South Asian patients with type 2 diabetes died 7.4 years younger than white Europeans (P=0.023), with a non-significantly higher risk of CVD events or death (OR 1.4; 95% CI 0.9-2.2).

synapsesocial.com/papers/6aa6233dc616a76b5feed6abhttps://doi.org/10.1185/03007995.2010.490468
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ethnicity and risk factors for coronary heart disease in diabetes mellitus2000 · 33 citations
  2. 2Risk Factors for Early Myocardial Infarction in South Asians Compared With Individuals in Other Countries2007 · 1,034 citations