Key result
Cardamonin inhibited the calcific transformation of human valve interstitial cells and ameliorated aortic valve calcification by inactivating the NF-κB/NLRP3 inflammasome.
Why the study?
Does Cardamonin inhibit osteogenic differentiation and ameliorate aortic valve calcification in human valve interstitial cells?
Does Cardamonin inhibit osteogenic differentiation and ameliorate aortic valve calcification in human valve interstitial cells?
Cardamonin is a promising natural compound that may prevent the progression of heart valve calcification by inhibiting the NF-κB/NLRP3 inflammasome pathway.
Hypothesis-generating for cardamonin in calcific aortic valve disease; prospective trials needed before clinical adoption.
, CDM ameliorated aortic valve calcification by interfering with NLRP3 expression. Our study demonstrated that CDM inhibited the phenotypical calcific transformation of hVICs by mediating the inactivation of the NF-κB/NLRP3 inflammasome. Therefore, it is considered to be a promising natural compound for use in preventing the progression of heart valve calcification disease.
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Wang et al. (2021) studied this question. Cardamonin inhibited the calcific transformation of human valve interstitial cells and ameliorated aortic valve calcification by inactivating the NF-κB/NLRP3 inflammasome.
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