Key result
CD44 knockdown reduces mineralization and upregulates OPN in calcific aortic valve disease models.
Why the study?
The lack of pharmaceutical targets for treating calcific aortic valve disease necessitates further research into disease-specific mechanisms involving valve interstitial cells and extracellular matrix components.
Does siRNA knockdown of CD44 reduce mineralization in valve interstitial cells in vitro?
Does siRNA knockdown of CD44 reduce mineralization in valve interstitial cells in vitro?
In vitro knockdown of CD44 reduces mineralization in valve interstitial cells, identifying a potential novel therapeutic target for calcific aortic valve disease.
Authors
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CD44 may be a target to limit aortic valve mineralization; leaves open whether effects translate beyond in vitro models.
Baugh et al. (2019) studied calcific aortic valve disease (CAVD). siRNA knockdown of CD44 was evaluated on mineralization / calcific nodule development. siRNA knockdown of CD44 reduced overall mineralization and upregulated OPN expression in an in vitro model of calcific aortic valve disease.
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