Key result
Culturing valvular interstitial cells on stiff substrates resulted in higher cell numbers, more pronounced αSMA-positive stress fibers, and larger spread area relative to compliant substrates.
Valvular interstitial cells are highly sensitive to substrate stiffness, highlighting the importance of mechanical properties in materials designed for heart valve repair or tissue engineering.
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Substrate stiffness may affect valvular interstitial cell behavior in repair materials; hypothesis-generating from animal cell data.
Quinlan et al. (2012) studied Valvular interstitial cell activation. Substrate stiffness vs. Compliant substrate was evaluated on Valvular interstitial cell activation (cell numbers, αSMA-positive stress fibers, spread area). Culturing valvular interstitial cells on stiff substrates resulted in higher cell numbers, more pronounced αSMA-positive stress fibers, and larger spread area relative to compliant substrates.
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