Key result
Children infected with HEV-71 genogroup B4 were less likely to develop CNS complications compared to those with other genogroups (15% vs 28%; OR 0.48; 95% CI 0.26-0.91; P=0.0223).
Population
773 children with suspected HEV-71, of whom 277 were infected with HEV-71.
Design
Cohort
Authors
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B4 genogroup infection was associated with lower CNS risk; hypothesis-generating and should not yet change pediatric monitoring or outbreak protocols.
Cohort (n=773)
Odds Ratio: 0.48 (95% CI 0.26–0.91)
Absolute Event Rate: 15% vs 28%
p-value: p=0.0223
HEV-71 genogroups differ in their risk of causing CNS complications, with genogroup B4 associated with a lower risk compared to other genogroups.
Ooi et al. (2007) conducted a cohort in Suspected HEV-71 (hand-foot-and-mouth disease, CNS disease, or both) (n=773). HEV-71 genogroup B4 vs. Other HEV-71 genogroups was evaluated on CNS complications (OR 0.48, 95% CI 0.26-0.91, p=0.0223). Children infected with HEV-71 genogroup B4 were less likely to develop CNS complications compared to those with other genogroups (15% vs 28%; OR 0.48; 95% CI 0.26-0.91; P=0.0223).
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