Key result
A multidisciplinary approach to complex dermal sarcomas, including advanced reconstructive techniques, can achieve optimal aesthetic and functional outcomes with low recurrence rates.
Why the study?
Primary dermal sarcomas often mimic benign soft tissue lesions, causing diagnostic delays, while local aggressive behavior in some forms causes surgical challenges requiring specialized multidisciplinary planning.
A multidisciplinary approach involving specialized surgical and medical specialties, including interdisciplinary microsurgeons, is essential for achieving optimal outcomes in complex dermal sarcomas.
Supports multidisciplinary care for complex dermal sarcomas; leaves open prospective validation before practice change.
Primary dermal sarcomas (PDS) belong to a highly clinically, genetically and pathologically heterogeneous group of rare malignant mesenchymal tumours primarily involving the dermis or the subcutaneous tissue. The tumours are classified according to the mesenchymal tissue from which they originate: dermal connective tissue, smooth muscle or vessels. Clinically, PDS may mimic benign soft tissue lesions such as dermatofibromas, hypertrophic scarring, etc. This may cause substantial diagnostic delay. As a group, PDS most commonly comprises the following clinicopathological forms of dermal sarcomas: dermatofibrosarcoma protuberans (DFSP), atypical fibroxanthoma (AFX), dermal undifferentiated pleomorphic sarcoma (DUPS), leiomyosarcoma (LMS), and vascular sarcomas (Kaposi's sarcoma, primary angiosarcoma, and radiation-induced angiosarcoma). This clinical entity has a broad spectrum regarding malignant potential; however, local aggressive behaviour in some forms causes surgical challenges. Preoperative, individualised surgical planning with complete free margins is pivotal along with a multidisciplinary approach and collaboration across highly specialised surgical and medical specialties. The present review gives a structured overview of the most common forms of dermal sarcomas including surgical recommendations and examples for advanced reconstructions as well as the current adjunctive medical treatment strategies. Optimal aesthetic and functional outcomes with low recurrence rates can be achieved by using a multidisciplinary approach to complex dermal sarcomas. In cases of extended local tumour invasion in dermal sarcomas, advanced reconstructive techniques can be applied, and the interdisciplinary microsurgeon should be an integral part of the sarcoma board.
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Trøstrup et al. (2022) conducted a review in Primary dermal sarcomas (PDS). Multidisciplinary approach and advanced reconstructive techniques was evaluated. A multidisciplinary approach to complex dermal sarcomas, including advanced reconstructive techniques, can achieve optimal aesthetic and functional outcomes with low recurrence rates.
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