January 9, 1982BMJOpen Access

Comparison of haemodynamic responses to dobutamine and salbutamol in cardiogenic shock after acute myocardial infarction.

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Why the study?

Does dobutamine compared to salbutamol improve haemodynamic responses in patients with cardiogenic shock after acute myocardial infarction?

Population

9 patients with critically reduced cardiac output (cardiogenic shock) after acute myocardial infarction

Comparison

Dobutamine (250-750 microgram/min) vs Salbutamol in a single cross-over comparison

Design

Case_series

Follow-up

Acute (during infusion)

Authors

MFMichael B. FowlerUniversity of North Carolina at Chapel Hill ATAdam TimmisInterventional Cardiology JCJ. C. P. CrickNIHR Bristol Cardiovascular Biomedical Research Unit

Discussion

Member takes

Implication

Case report does not support changing inotrope choice; leaves open need for randomized comparison in cardiogenic shock.

Structured PICO

Does dobutamine compared to salbutamol improve haemodynamic responses in patients with cardiogenic shock after acute myocardial infarction?

Population

9 patients with critically reduced cardiac output (cardiogenic shock) after acute myocardial infarction

Intervention

Dobutamine (250-750 microgram/min)

Comparator

Salbutamol (10-40 microgram/min) in a single cross-over comparison

Outcome

Haemodynamic responses including cardiac index, systemic blood pressure, systemic vascular resistance, heart rate, stroke index, and pulmonary artery end-diastolic pressuresurrogate

Dobutamine and salbutamol have similar haemodynamic effects in cardiogenic shock post-MI, but dobutamine may be more beneficial due to its reduction of pulmonary artery end-diastolic pressure.

Cite This Study

Fowler et al. (1982) studied this question.

synapsesocial.com/papers/6a75bcae06e84d3015dd8440 https://doi.org/10.1136/bmj.284.6309.73

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