Key result
Salbutamol infusion significantly increased cardiac index by up to 56.7% and reduced systemic vascular resistance, but failed to reduce left ventricular filling pressure.
Why the study?
Does salbutamol infusion improve haemodynamic parameters in patients with acute myocardial infarction complicated by left ventricular failure?
Population
11 patients with acute myocardial infarction complicated by left ventricular failure.
Design
Case_series
Authors
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May support haemodynamic stabilization in acute MI with LV failure; leaves open efficacy and safety in randomized contemporary trials.
Does salbutamol infusion improve haemodynamic parameters in patients with acute myocardial infarction complicated by left ventricular failure?
Effect estimate: 56.7% increase
Absolute Event Rate: 2.8% vs 1.8%
p-value: p=<0.01
Salbutamol increases cardiac output in low-output states following acute myocardial infarction but fails to reduce left ventricular filling pressure, making it unsuitable for treating pulmonary oedema in this setting.
Timmis et al. (1979) studied Acute myocardial infarction with severe left ventricular dysfunction (n=11). Salbutamol vs. Baseline was evaluated on Cardiac index (L/min/m2) at 40 µg/min (56.7% increase, p=<0.01). Salbutamol infusion significantly increased cardiac index by up to 56.7% and reduced systemic vascular resistance, but failed to reduce left ventricular filling pressure.
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