Key result
Quercetin treatment at 10 mg/kg protected rats from the progression of experimental autoimmune myocarditis to dilated cardiomyopathy by suppressing ER stress and myocardial fibrosis.
Why the study?
Does quercetin 10 mg/kg prevent the progression of experimental autoimmune myocarditis to dilated cardiomyopathy in a rat model?
Does quercetin 10 mg/kg prevent the progression of experimental autoimmune myocarditis to dilated cardiomyopathy in a rat model?
Quercetin at 10 mg/kg protects against the progression of experimental autoimmune myocarditis to dilated cardiomyopathy in rats by modulating ER stress and MAPK signaling.
Hypothesis-generating in rat autoimmune myocarditis; leaves open translation to human dilated cardiomyopathy prevention.
In order to test the hypothesis that treatment with quercetin at a dose of 10 mg/kg protects from the progression of experimental autoimmune myocarditis (EAM) to dilated cardiomyopathy (DCM), we have used the rat model of EAM induced by porcine cardiac myosin. Our results identified that the post-myocarditis rats suffered from elevated endoplasmic reticulum (ER) stress and adverse cardiac remodelling in the form of myocardial fibrosis, whereas the rats treated with quercetin have been protected from these changes as evidenced by the decreased myocardial levels of ER stress and fibrosis markers when compared with the vehicle-treated DCM rats. In addition, the myocardial dimensions and cardiac function were preserved significantly in the quercetin-treated rats in comparison with the DCM rats treated with vehicle alone. Interestingly, the rats treated with quercetin showed significant suppression of the myocardial endothelin-1 and also the mitogen activated protein kinases (MAPK) suggesting that the protection offered by quercetin treatment against progression of EAM involves the modulation of MAPK signalling cascade. Collectively, the present study provides data to support the role of quercetin in protecting the hearts of the rats with post myocarditis DCM.
No takes yet. Share an insight, caveat, or question.
Arumugam et al. (2011) studied Experimental autoimmune myocarditis (EAM) / dilated cardiomyopathy (DCM). Quercetin vs. Vehicle was evaluated on Progression of EAM to dilated cardiomyopathy, ER stress, and myocardial fibrosis. Quercetin treatment at 10 mg/kg protected rats from the progression of experimental autoimmune myocarditis to dilated cardiomyopathy by suppressing ER stress and myocardial fibrosis.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: