Key result
Paraoxonase 1 (PON-1) activity and oxidative stress index were independent predictors for contrast-induced nephropathy in patients with anterior STEMI undergoing primary PCI.
Why the study?
Do paraoxonase 1 (PON-1) activity and oxidative stress markers predict contrast-induced nephropathy in patients with anterior STEMI undergoing primary PCI?
Cohort (n=289)
Do paraoxonase 1 (PON-1) activity and oxidative stress markers predict contrast-induced nephropathy in patients with anterior STEMI undergoing primary PCI?
p-value: p=<.05
Lower PON-1 activity and higher oxidative stress index are independent predictors of contrast-induced nephropathy in STEMI patients undergoing primary PCI.
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Supports biomarker-based risk stratification in anterior STEMI; leaves open whether modulating oxidative stress reduces contrast-induced nephropathy.
Börekçi et al. (2014) conducted a cohort in anterior ST-segment elevation myocardial infarction (STEMI) (n=289). Paraoxonase 1 (PON-1) activity and oxidative stress markers was evaluated on Contrast-induced nephropathy (CIN) (p=<.05). Paraoxonase 1 (PON-1) activity and oxidative stress index were independent predictors for contrast-induced nephropathy in patients with anterior STEMI undergoing primary PCI.
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